Dipeptidyl peptidase



Dipeptidyl peptidase (DPP) is an enzyme which cleaves dipeptides from plolypeptides. DPP-IV (or CD26) cleaves proline dipeptides from the N-termini and is associated with immune regulation. DPP-III acts similarly to DPP-IV. DPP-I is involved in inflammatory diseases. DPP-II is a serine protease. The images at the left and at the right correspond to one representative DPP, i.e. the crystal structure of Dipeptidyl peptidase-I from rat (1jqp).

3D Structures of Dipeptidyl peptidase
Update June 2011

DPP-I
1jqp – rDPP-I – rat

DPP-II
3n0t – hDPP-II peptidase domain residues 28-492+inhibitor - human

3jyh – hDPP-II peptidase domain residues 28-492

DPP-III
3fvy – hDPP-III

3csk – DPP-III (mutant) – yeast

DPP-IV
2onc, 1tk3, 1r9m, 1j2e, 1nu6, 1pfq – hDPP-IV extracellular domain

1u8e – hDPP-IV extracellular domain (mutant)

3kwj, 3oc0, 3kwf, 3q8w – hDPP-IV extracellular domain +quinoline derivative

3g0b, 3g0d, 3g0g, 3nox, 3hab, 3hac, 3f8s, 3h0c, 3ccb, 3ccc, 2qjr, 2qky, 3d4l, 2jid, 3bjm, 2rip, 2ole, 2rgu, 2i78, 2oag, 2oqv, 2oqi, 2ogz, 2i03, 2g5p, 2g5t, 2g63, 2bub, 2ajl, 1wcy, 1rwq, 1tkr, 1n1m, 3eio, 3g0c – hDPP-IV extracellular domain+inhibitor

1r9n, 2bgr, 1nu8 – hDPP-IV extracellular domain+polypeptide

1w1i – hDPP-IV extracellular domain+adenosine deaminase

2bgn – hDPP-IV extracellular domain+adenosine deaminase+polypeptide

3c43, 3c45, 2qoe, 2qt9, 2qtb, 2p8s, 2oph, 2fjp, 1x70, 2iit, 2iiv – hDPP-IV extracellular domain (mutant)+inhibitor

3o95, 3o9v - hDPP-IV + inhibitor

2gbc – rDPP-IV extracellular domain

2oae, 2i3z, 2gbf, 2gbg, 2gbi – rDPP-IV extracellular domain+inhibitor

2aj8, 2ajb, 2ajc, 2ajd, 2bua, 2buc, 1orw – pDPP-IV extracellular domain+inhibitor - pig

1orv - pDPP-IV extracellular domain

2ecf - DPP-IV – Stenotrophomonas maltophilia